The Newcastle upon Tyne Hospitals NHS Foundation Trust (NUTH) is one of the busiest, largest and most successful teaching NHS foundation trusts in the UK with 14,000 staff and an annual income of over £1.1billion. We have a long history of providing high quality care, clinical excellence and innovation in medical research regionally and (inter)nationally, and for the second time running were rated ‘outstanding’ organisation by the Care Quality Commission 2019. We treat over 1.7 million people each year, delivering more specialities than any other hospital in England. These include a range of flagship services which deliver cutting-edge care (supported by state-of-the-art diagnostic services in both radiology and pathology) and are a catalyst for innovation to support pioneering clinical practice in the NHS, including the Great North Children’s Hospital which provides the full range of children’s health services including immunology treatments where we are recognised as one of the leading clinical research units in Europe for paediatric immunology and infectious diseases. The recent GMC survey of doctors in training scored the North-East Hospitals as a group as best in 14 of 18 categories. We have recruited more patients into adult and paediatric research studies and clinical trials than any other hospital in the NHS every year for the last 7 years. Patients will be recruited in the project from The Children’s Directorate of the Great North Children’s Hospital (GNCH) including the Paediatric Intensive Care Unit (PICU), the Paediatric Bone Marrow Transplant Service, and Paediatric Oncology Service, and paediatric and adult Rheumatology.
Building on past and current experience in e.g. FP7EUCLIDS and H2020 PERFORM, for which we have recruited a vast number of patients (>4000), Newcastle University will recruit patients for DIAMONDS. NUTH, with Newcastle University will lead on the recruitment and assigning of categories for high risk patients. In addition, NUTH will contribute a very well characterised cohort of patients with early rheumatoid arthritis. Additionally, NUTH will contribute to patient participation engagement and co-production, using established relationships with diverse groups of young people and their carers.
The Paediatric Oncology department provides a regional service to northern England with about 110 new patients per annum and has over 1000 children on treatment or in long-term follow up. The Department is 1 of 3 centres in the UK for CAR-T cell therapy and is the Northern centre for Paediatric Phase 1 studies. We have a large Paediatric stem cell-transplant and infectious diseases unit. The Great North Children’s Hospital Paediatric Intensive Care Unit (PICU) is an 18 bedded unit, the Freeman Hospital PICU is a 10 bedded cardiac PICU. With approximately 1000 admissions/year, NUTH is the 5th largest PICU in the UK. All interventions are available, including Extracorporeal membrane oxygenation (ECMO).
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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 848196